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In CKD patients, reduced corin expression in the kidney and decreased urinary soluble corin levels have been reported [58] whereas its overexpression in the UUO model attenuated fibrosis progression [59]

Maternal RPM supplementation, utilizing two different products available in the market (Smartamine M or MetaSmart) during the last 21 days of gestation, promoted a reduction in plasma positive acute-phase proteins, accompanied by a decrease in plasma IL-6 after calving, indicating a reduction in proinflammatory responses (Osorio et al., 2014b)

Gut microbiota dysbiosis can also induce an inflammatory response and affect the metabolism of bile acids (BAs), short-chain fatty acids (SCFAs), trimethylamine-N-oxide (TMAO) and other bioactive molecules, resulting in systemic inflammation and endothelial dysfunction

FIGURE 6 The COVID-19 pandemic, caused by the 2019 novel coronavirus, is spreading globally