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The current findings disagree with Wantanable and colleagues , who observed a good evidence favoring efficacy of topical oxidized glutathione 2% lotion when applied twice daily for 10 weeks in producing skin whitening and also statistically significant reduction of skin melanin index by using Mexameter (a tool objectively measures melanin index of the skin) compared with placebo

The results can last from a few days to several weeks, depending on the formulation used and individual factors like metabolism and lifestyle

It serves as a cofactor for glutathione peroxidases, and is involved in the regulation of the nitric oxide cycle