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Other reports of sporadic, unclassified CDA may be found in the literature, often in association with other somatic abnormalities

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Since only partial information is available for each class, analyzing microarray experiments represents a valuable approach ahead of targeted expression studies

Extensive research has demonstrated the long-lasting anti-inflammatory properties of lutein by blocking multiple inflammation pathways and mediators such as NF-B, phosphatidylinositol 3-kinase (PI3K)/Akt, nuclear factor erythroid 2-related factor 2 (Nrf2), heme oxygenase-1 (HO-1), and sirtuin-1 (SIRT-1) signaling [32]