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Regarding MetS-related nephropathy, therapeutic studies of SCFAs have been conducted in both clinical investigations and animal experiments

doi: 10.1001/jamanetworkopen.2023.5626 52 IsraelABerkovitchMMerzonEGolan-CohenAGreenIRuppinEet al

In mice with global inactivation of the IGF-I gene, the proportionally reduced kidney size associates with reduced glomerular size and decreased numbers of nephrons[362]

The authors report that the benefit of AA was dose dependent and hypothesize that both dopaminergic and glutamatergic mechanisms mediate AAs protective actions