benefits of glutathione aging in Skin and Tissue Regeneration: A Systematic Review Molecular Mechanisms, Redox Modulation, and Biomedical Implications Glutathione IV Therapy - Philip

Stem Cells Int

One such trial, from 2020, had inconclusive results on SS-31s benefits for heart failure, but it described the peptide as well tolerated and reported no significant increases in blood pressure, heart rate, or electrocardiogram intervals.29 Another trial, from the same year, yielded no significant benefit for mitochondrial myopathy but found the only noteworthy adverse effects to be injection site reactions, the majority of which were mild.35 These findings are consistent with the risks described by the clinicians we know who prescribe SS-31, though they add that some users may also experience headaches , dizziness , gastrointestinal distress , flushing , or fatigue

Moreover, glycyrrhizin can inhibit the expression of fibrosis-related factors such as Connective Tissue Growth Factor (CTGF), Matrix Metalloproteinase (MMP2), and MMP9, reducing basement membrane disruption and inflammatory cell infiltration (Liang et al., 2015)

Disclosure of interest: Disclosures: Gtz Thomalla reports funding from the European Commission (EU Horizon 2020 research and innovation programme, payments to the institution) and personal consulting fees from Acandis, AstraZeneca, Bayer, Boehringer Ingelheim, and Stryker