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The Bcl-2 inhibitors synergized the cytotoxicity of PPI Similar to previous results 18,23,24 , in gastric cancer cells, caspase activation is involved in PPI-induced cell death, but caspase inhibition could only partially reduce PPI-induced cell death in both conditions (data not shown)

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Moreover, both cell lines also showed a significant increase in the expression of hexokinase 2 (HK2), which enables the measurement of glycolysis following glucose transport into the cell via the glucose transporter 33

4.2 Glutathione peroxidase GPx (GSH 2 :H 2 O 2 oxidoreductase, EC 1.11.1.9) is an intracellular antioxidant enzyme that contributes to prevent H 2 O 2 accumulation in cells