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In cancer biology and neurodegenerative disease, NNMT-driven SAM depletion alters epigenetic landscapes and gene expression patterns critical for cellular survival

31 Phenformin has been reported to exhibit anti-thiamine activity in animals, 3234 and as a result, it has been suggested that a possible anti-thiamine effect of metformin might contribute to some cases of metformin-associated lactic acidosis, a rare condition, but one that has been shown to have a mortality rate of 1825%

"Esses peptdeos, resumindo, funcionam como mensageiros biolgicos e enviam uma mensagem para a clula realizar determinada funo", explica Elisa Minami, cirurgi plstica e membro titular da Sociedade Brasileira de Cirurgia Plstica (SBCP)

Hamilton, S