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Furthermore, nebulized human platelet-derived exosome products have been shown to reduce smoke-induced emphysema in mice by inhibiting NF-B activation, inflammatory cytokine production and apoptotic protein expression, while promoting an increase in CD4+/forkhead box P3+ regulatory T cells in lung tissue, thereby alleviating oxidative lung injury, inflammation and apoptotic alveolar epithelial cell death (95)

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For example, Belchamber et al reported mitochondrial dysfunction in COPD macrophages