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Metabolic reprogramming in brain tumors

The mutation Mutation Genetic mutations are errors in DNA that can cause protein misfolding and dysfunction

Similar content being viewed by others Introduction While currently available therapies have substantially improved the clinical outcomes of many patients with kidney cancers, these treatments are typically ineffective against highly aggressive SMARCB1-deficient kidney malignancies such as renal medullary carcinoma (RMC) 1,2,3,4

However, such methods require the design and synthesis of rather complex bi-functional and tri-functional capture probes, which comprise the drug, a warhead or photoreactive group and an enrichment tag 4,5