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However, a recently published phase II clinical trial using the iron chelator deferiprone reported that deferiprone was ineffective in newly diagnosed PD patients who had not previously received dopaminergic therapy and even worsened both motor and non-motor symptoms [177]

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Hou L, Honaker MT, Shireman LM, Balogh LM, Roberts AG, Ng KC, et al

Thus, ALKBH5 supports stem cell self-renewal and multilineage potential by preventing excessive m6A methylation that would otherwise mark transcripts for degradation or altered splicing