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10.1016/j.jpeds.2021.12.049 8

[23] In one study, when NAC was added to rat bone marrow cultures, significant improvements were seen in the activity of alkaline phosphatase (levels of which increase when bones are growing) and osteoblastic cultures (cells that develop bone), as well as an upregulation of bone-related gene markers such as collagen

Mutational alterations of a key cis proline residue results in the trapping of enzymatic reaction intermediates of DsbA, a member of the thioredoxin superfamily