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This accumulation can damage performance of pancreatic islet -cells through lipotoxicity, exacerbate impaired insulin action, impair glucose metabolism, and ultimately lead to hyperglycemia and hyperinsulinemia, creating a vicious cycle

People who regularly consume soda or processed juices also have a higher risk of depression [272]

This orphan status has created a dichotomy in the scientific community: while empirical evidence from animal models and human clinical trials in the 1980s demonstrated significant therapeutic potential, particularly in addiction and stress management, the lack of a defined molecular pathway has stalled its development into a licensed pharmaceutical agent