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Second, Al-induced H + extrusion under acid stress could increase NO 3 - transport across the membrane via H + /NO 3 - co-transport

For example, high baseline CD3 + , CD8 + T cell infiltration may be evident early on, with frameshift mutations in the microsatellite regions of 2M gene, contributing to treatment resistance via loss of 2M, with subsequent loss of MHC class I presentation and decreased sensitivity to cytotoxic T celldirected therapies (e.g., anti-programmed cell death protein 1 (PD-1) therapies) [37, 76]

Hence, in order to fully exploit the therapeutic potential of mitochondrial targeted agents, it is essential to fully understand the mechanisms of action of mitochondrial-targeting agents

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