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Collagen deficiency is largely driven by the modern diet of lean, boneless, skinless meats, along with high sugar intake, chronic stress, and poor sleep

Taken together, during RA, macrophages produce proinflammatory cytokines, chemokines, and free radicals to activate immune and non-immune cells, leading to joint inflammation and destruction

Therefore, a pan-coronavirus vaccine that is able to induce immunity targeting combinations of epitopes conserved across the whole coronavirus family should also protect against future variants and emerging viral species, in which these epitopes will likely be retained owing to functional constraints

Khangembam et al