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LIST OF ABBREVIATIONS ACE2 Angiotensin-converting Enzyme 2 Receptor ARDS Acute Respiratory Distress Syndrome BBB Blood-brain Barrier BCB Blood-cerebrospinal Fluid Barrier BDNF Brain-derived Neurotrophic Factor cAMP cyclic Adenosine Mono-phosphate CFS Chronic Fatigue Syndrome CNS Central Nervous System CVOs Circum Ventricular Organs DLPFC Dorso-Lateral Prefrontal Cortex DPP4 Dipeptidyl-peptidase 4 Receptor EAAT2 Excitatory Amino-acid Transporter 2 GCPII Glutamate Carboxypeptidase II GDNF Glial Cell-derived Neurotrophic Factor GFAP Glial Fibrillary Acidic Protein GSH Glutathione IFN Interferon IL Interleukin KYNA Kynurenic Acid MCP Monocyte Chemoattractant Protein mGlu Metabotropic Glutamate Receptor MODS Multiple Organ Dysfunction Syndrome NAC N-Acetyl Cysteine NEMO Nf-kB Essential Modulator Nf-kB Nuclear Factor Kb NGF Nerve Growth Factor NICE National Institute for Care Excellence NMDA N-methyl-D-aspartate Receptor Nrf2 Nuclear Factor Erythroid 2-related Factor PCS Post-Covid Syndrome PTSD Post-traumatic Stress Disorder REST Repressor Element one Silencing Transcription Factor RNS Reactive Nitrogen Species ROS Reactive Oxygen Species TfR1 Transferrin Receptor TLR7 Toll-like Receptor 7 TNF Tumoral Necrosis Factor Xct Cystine-glutamate Antiporter AUTHORS CONTRIBUTIONS T.B., F.P., and A.C

144 Efinopegdutide is a dual agonist for GLP-1R and GIPR

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Conclusion BPC-157 is a synthetic 15-amino-acid peptide that continues to attract attention within peptide research