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doi: 10.1111/j.1742-1241.2010.02376.x

ZC: Funding acquisition, Resources, Validation, Writing original draft, Writing review & editing

FEBS letters , 238 (2), 343346

Abstinence, however, may require medical guidance, as withdrawal and recovery from dependence can also lead to sleep disturbances, such as greater difficulty falling asleep, frequent awakenings, reduced restorative sleep (slow wave sleep), and prolonged REM periods (REM rebound), all of which may lead to fatigue during the day