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ACSL4 catalyzes the attachment of free PUFAs to coenzyme A to generate PUFA-CoAs, which are re-esterified and incorporated into phospholipids (PLs) by LPCAT3 to form PUFA-containing phospholipids (PUFA-PLs) ( The downregulation of PUFAs in tumour cells is associated with ferroptosis evasion and the promotion of tumour growth (Figure 1

Results HGT1 overexpression causes toxic accumulation of GSH Hgt1 is an exclusive GSH and GSSG transporter (Bourbouloux et al , 2000)

588,589 -syn is functionally associated with iron, calcium, and lipid metabolism, and its aggregation has been found to induce ferroptosis by interacting with cellular membrane and accelerating lipid peroxidation

MicroRNA-218 increases the sensitivity of bladder cancer to cisplatin by targeting Glut1