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However, an overproduction of probiotic metabolites like peptidoglycan fragments or bacterial DNA can hyperactivate DCs via TLR2/9 or NOD2, boosting BAFF/APRIL production via NF-B/MAPK pathways, potentially triggering systemic autoreactive B cells and exacerbating SLE autoimmunity (139141)

Both neurogenic inflammation and oxidative stress are key factors in migraine development, and topiramates neuroprotective potential through its anti-inflammatory and antioxidative effects is noted

[DOI] [PubMed] [Google Scholar] Patel, C