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[24] [10] [25] Four trials were conducted in ED, the last being a Phase IIb published in 2008

Moreover, the evaluation of pigmented lesions in the oral cavity is further complicated by multifactorial etiologies, including endogenous factors like nevi and exogenous causes such as amalgam tattoos, making accurate diagnosis and management of these lesions pivotal in clinical practice

If a patient finds themselves needing it more often than 2 doses per week, a re-evaluation of underlying issues or alternative therapies may be warranted