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In addition, we observed the lowest intracellular green fluorescence intensity in CDCZA-treated cells, showing that CDCZA nanoparticles could effectively achieve intracellular GSH depletion, which might be the result of the effective cellular uptake of CDCZA nanoparticles, and the released Cur/Cu 2+ -mediated GSH consumption

the engineered antibody may be composed of one or more CDRs that are, for example, 90%, 95%, 98%, 99% or 99.5% identical to one or more CDRs of the M25ADLF, M25ADLFEG, M25ADLFDS, M25FYIA, M25FYIAEG, M25FYIADS, M25, M25EG, M25DS, one or more residues of a CDR may be altered to modify binding to achieve a more favored on-rate of binding