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As required under section 1847A(i)(3)(G)(ii) of the Act, CMS will reduce the total rebate amount determined under 427.301(a), if any is owed, for a Part B rebatable biosimilar biological product when CMS determines there is a severe supply chain disruption during the applicable calendar quarter such as that caused by a natural disaster or other unique or unexpected event

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Studies have also explored its potential influence on hormone release, oxidative stress, and neuroprotection