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V.ForresterT.HibbertJ

In contrast, knock down of Nrf2 suppresses tumor growth, inhibits cell proliferation and promotes increased apoptosis [44, 49]

Its unique biochemical stability, targeted tissue uptake, and capacity to limit oxidative and metal-mediated damage distinguish it from many conventional antioxidants

Indeed, inhibition of enzymatic antioxidants and accumulation of excess levels of ROS generate OS in the ovary that directly affects oocyte quality and thereby reproductive outcome[10,14,64,65]