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The chronic hyperglycemia of diabetes is associated with long-term damage, dysfunction, and failure of various organ systems, especially the eyes, kidneys, nerves, heart, and blood vessels ( Diabetic retinopathy (DR) is the most common microvascular complication of DM and is a leading cause of blindness in the working age population worldwide ( Clinically, DR is classified into two progressive stages termed non-proliferative DR (NPDR) and proliferative DR (PDR)

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Some studies have shown that although the application of curcumin can effectively reduce fasting blood glucose and dehydroepiandrosterone (DHEA) levels in PCOS patients, it has no obvious improvement on IR indicators (Heshmati et al., 2021)