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less than 1% develop hemolytic anemia (methyldopa) Sleep disturbances, drowsiness, or dry mouth Symptoms of depression Impotence Pulse Rebound hypertension Reprinted with permission from JNC-VII

In a subset of liver fluke-positive CCAs (cluster 1), global hypermethylation was linked to ARID1A and BRCA1/2 mutations and increased gene promoter alterations related to histone 3 lysine 27 trimethylation, predicted to affect transcription factor binding and, consequently, gene expression 74

Gibbons, J