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Neither homozygous nor heterozygous p.H63D or p.S65C mutations lead to iron overload and are not relevant for the HC diagnosis [12,26,77]

HBV induces tumorigenesis by altering the host immune microenvironment During HBV infection, CTL cells are severely depleted, and remaining CD8 + and CD4 + T cells upregulate inhibitory receptors

Long COVID patients consistently show: 13 Persistent gut dysbiosis with reduced microbial diversity lasting months after infection Depletion of butyrate-producing bacteria leading to reduced SCFA production and impaired immune regulation SARS-CoV-2mediated ACE2 downregulation disrupting renin-angiotensin system (RAS) balance and gut microbial homeostasis Increased intestinal permeability allowing endotoxin (LPS) translocation and systemic cytokine activation Gutorgan axis disruption contributing to respiratory, neurologic, cardiovascular, renal, and musculoskeletal symptoms Some studies have identified persistent viral RNA in gut tissue, suggesting the gastrointestinal tract may serve as a viral reservoir

Yizhou Dong at The Ohio State University