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Decreased expression of tight junction proteins (ZO-1, Occludin, Claudin-1) facilitates the translocation of endotoxins such as LPS into the bloodstream, further amplifying inflammatory damage ( Gut microbiota dysbiosis is a key factor in UC pathogenesis, influencing intestinal physiology and systemic inflammation via the gut-microbiota-host axis

Glutathione is a powerful antioxidant naturally found in the body, involved in reducing oxidative stress and boosting the immune system

Although the survival advantage of this combined treatment regimen was still evident at 5 years, the increase in overall median survival was only for 2.5 months

7 Conclusion and future perspectives Huperzine A, a naturally derived and reversible acetylcholinesterase inhibitor, demonstrates strong neuroprotective and cognitive-enhancing effects, particularly in Alzheimers disease (AD)