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In cases where a patient was found unsuitable for KD, the expert team provided further guidance and advice based on the patient's condition, referring them back to the committee for vagal nervous stimulation (VNS) or palliative epilepsy surgery

This synergy effect may arise because pathway inhibitors can block the downstream survival signals, while DNA methyltransferase inhibitors (DNMTi) can restore the expression of tumor suppressor genes, making cells more sensitive to apoptosis

The empirical data support this hypothesis, demonstrating significant improvements in key physiological parametersspecifically the respiratory quotient, heart rate, and perceived exertion as measured by the Borg scaleunder our experimental protocol

The transmembrane protein CPT1 is located at the outer mitochondrial membrane, while CPT2 is in the inner of the mitochondrial membrane (Fraser et al., 1997)