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Gene expression levels were quantified using RSEM (Li and Dewey, 2011), and differential expression analysis was conducted using DESeq2 (Anders and Huber, 2010)

In these tissues, glucose uptake is mediated by GLUT proteins other than GLUT-4 and so does not require insulin

Conversely, individuals with high PEM/E , low NEM/N and low AI would be least vulnerable (most resilient) to SUD ( Figure 3 To our initial analysis, we added CI as an additional personality trait, modulated by a circuit including glutamatergic neurons from the ventromedial prefrontal cortex and the posterior cingular cortex that innervate the ventral striatum (nucleus accumbens) and, as with AI , is also moderated by the D 4 R gene, and by the gene of the enzyme catechol- O -methyltransferase ( Figure 3 )