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However, their function in DKD is still unclear

Due to its fundamental role in maintaining cellular homeostasis, glutathione remains one of the most widely studied endogenous molecules in redox biology and metabolic research

This suggests that metabolic rewiring via lipid pathways is a non-canonical mechanism by which the autophagy-ferroptosis balance is tilted toward tumor promotion

Simple structural modifications converting a bona fide MDM2 PROTAC degrader into a molecular glue molecule: a cautionary tale in the design of PROTAC degraders