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Finally , future correlative studies of clinical trials should strive to have paired tumor biopsiesideally collected longitudinally during ARPI treatment and progression, which will help define how ETS fusion status, AR activity, and BCL-2 expression interact in patients

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Nevertheless, these cholangiographic features are not specific for cholangiocarcinoma and can be seen in the absence of malignancy (MacCarty et al, 1985)

We analyzed changes in the active cecal microbiota using ribosomal RNA sequences identified in the metatranscriptome data (Fig