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A therapeutically useful arginine depleting agent for cancer treatment should have low toxicity, non-immunogenic (to prevent antibody production and allergic reactions) and fast-acting (to delay emergence of drug resistance) with long circulation half-life (to achieve sustained arginine depletion)

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Concurrently, tumor-intrinsic factorshypoxia, immunosuppressive stroma, and heterogeneous anatomyfurther reduce radiosensitivity and compromise tumor coverage [16, 17]