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Its analgesic effects appear to be primarily mediated through the activation of opioid receptors and the L-arginine/NO/cGMP signaling pathway

[DOI] [PMC free article] [PubMed] [Google Scholar] Baudry M., Etienne S., Bruce A., Palucki M., Jacobsen E., Malfroy B

NF-B present in an active form in the elderly, is a principal transcription protein involved in senoinflammation and its activity is connected to common aging regulators, including DNA damage, mTOR, SIRT, FOXO, and IGF-1 [140]