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112 (2): e1325

Tumor development is triggered by the stimulation or disruption of signaling pathways at the cellular level as a result of the interaction between cells and environmental stimuli (Petric et al., 2015

In this regard, it has been observed that an increase in the consumption of n-6 polyunsaturated fatty acids (PUFA) together with a decrease in the consumption of n-3 polyunsaturated fatty acids (PUFA) led to an increase in childhood asthma (316, 317)

Of the other sites we propose, some are more likely than others, but those in TXNRD1 and SELENOF are particularly convincing, and all of the predicted sites map to surface accessible regions of the targeted proteins (Figure S3)