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When cells are exposed to increased levels of oxidative stress, GSSG accumulates and the ratio of GSH/GSSG decreases to ratios as low as 10:1 and even 1:1

doi: 10.1215/15228517-2008-095 231 BernardiRJLoweryARThompsonPABlaneySMWestJL

the most abundant phospholipid in mammalian cells) was elevated in the kidneys of vehicle-treated mice (Figure 5E)

It has to distinguished that the replacement therapy should be only undertaken to restore the physiological levels, never to exceed physiological ranges