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Environ Res 236:116851

Initial contact with an antigen triggers one or other type of reaction, through a poorly understood mechanism that appears to involve the type of antigen, its size (large antigens tend to induce Th1 reactions), its concentration (low concentrations tend to induce Th2 responses), and stimulatory cofactors released by the APC (the presence of gamma interferon and/or IL-2 induces a Th1 response, while IL-4 induces a Th2 response)