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By blocking the effects of certain neurotransmitters involved in cravings and reward-seeking behavior, naltrexone can help reduce the desire for high-calorie foods and promote healthier eating habits

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Disclosures: Taisei Keitoku: Nothing to Disclose, Nobuharu Tamaki: Nothing to Disclose, Masayuki Kurosaki: Nothing to Disclose 443 IMPACT OF PRE-TRANSPLANT IMMUNE CHECKPOINT INHIBITORS ON DOWNSTAGING OUTCOMES: A PROSPECTIVE INTENTION-TO-TREAT ANALYSIS FROM A MULTI-CENTER US STUDY Parissa Tabrizian 1 Matthew Holzner 2 Edison Xu 3 Maarouf Hoteit 4 Veeral Ajmera 5 Tara Ghaziani 6 Neehar Parikh 7 Kali Zhou 8 Amy Kim 9 Rebecca Marino 2 Francis Yao 3 Sander Florman 2 Neil Mehta 3 , 1 Mount Sinai Medical Center NY/RMTI, 2 Mount Sinai Medical Center NY, RMTI, 3 University of California, San Francisco, 4 University of Pennsylvania, 5 University of California San Diego, 6 Stanford University, 7 University of Michigan Medical Center, 8 University of Southern California, 9 Johns Hopkins School of Medicine Background: The use of immune checkpoint inhibitors (ICI) in patients with advanced hepatocellular carcinoma (HCC) has shown promising outcomes