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However, unlike Navitoclax, which can be administered orally and has good bioavailability [102], ABT737 poorly dissolves in water, and its biological availability is low [87]

Key takeaways: Peptides are not the same as steroids Safety depends on the compound and dosage Medical supervision greatly improves peptide therapy safety While peptide research continues to evolve, responsible clinical use remains the most reliable way to ensure safety

13-6800, Thermo Fisher Scientific), anti-SYNCRIP (R5653, Sigma-Aldrich), anti-SIRT1 (ab110304, Abcam, UK), anti-NRF2 (NBP1-32822, Novus, USA), anti-xCT (ab37185, Abcam), anti-GPX4 (ab125066, Abcam), anti-GFP (2956, Cell Signaling, USA), anti-Cleaved caspase 3 (9661, Cell Signaling), anti-PRDX3 (A304-744A, Bethyl Laboratories, USA), anti-PRDX5 (A305-339A, Bethyl Laboratories), anti-HK2 (ab209847, Abcam), and anti-ACTIN (A5316, Sigma- Aldrich, USA)

Alzheimers & Dementia 19:658670