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Parian AM, Limnetic BN, Shah ND, Mullin GE

Computational prediction plays a crucial role in prediction of hypothetical metabolic reactions by leveraging existing knowledge of metabolic networks, enzyme functions, and chemical transformations, which includes the homology-based enzyme function annotation 13 , constraint-based genome-scale metabolic modeling 14 , and machine learning-based prediction 15,16

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Evolving research indicates more heterogeneous pathomechanisms observed in melasma, including solar elastosis, increased vascularization, and an increased number of senescent fibroblasts, in addition to the inappropriate melanocyte activation 7,8