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Description

previously reported that treating SOD1 G37R mice (a model of ALS) with the therapeutic Cu-delivery agent Cu II (atsm) restored Cu content in mutant SOD1 proteins and increased survival

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Die Dosierungsempfehlung bewegt sich zwischen 400 mg und 1000 mg am Tag

To generate truncated ChiB proteins lacking either the N- or the C-terminus or a ChiB protein lacking the loop region, PCR was performed with specific oligonucleotides (Table S5) and the PCRBIO HiFi polymerase (PCR Biosystems, London, UK) applying the identical conditions as stated above