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Other reported mechanisms include activation of FAK-paxillin complexes (which help cells migrate and attach to surfaces during wound healing), JAK-2 signaling, and ERK1/2 pathway activity (Sikiric et al., Current Neuropharmacology, 2016

To calculate the proportion of trials employing digital technologies, supplementary searches were performed on ClinicalTrials.gov to identify all interventional trials related to each rare disease, with these totals serving as denominators

Oxidative stress induces a form of programmed cell death with characteristics of both apoptosis and necrosis in neuronal cells