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The observed aggregates likely result from the inherent stickiness of Syn 1103 , wherein the exposure of its hydrophobic region slows diffusion and promotes promiscuous interactions with various cellular proteins, thereby interfering with their normal functions

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The neurodevelopmental disorders in children are the most prevalent disabilities encountered in pediatric health services, which include autism spectrum disorder (ASD), attention deficit hyperactivity disorder (ADHD), intellectual disability (mental retardation), cerebral palsy (CP), learning disabilities, neurodevelopmental motor disorders, conduct disorders, impairment in vision and hearing [2,3,4], with ASD and ADHD the most common of the NDDs

Beyond its cytoskeletal effects, TB-500 forms functional complexes with PINCH (particularly interesting new cysteine-histidine-rich protein) and integrin-linked kinase (ILK), activating the survival kinase Akt while inhibiting TNF--induced NF-B activation through blocking of RelA/p65 translocation