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On the one hand, iron overload led to endothelial dysfunction by enhancing the oxidative and inflammatory responses in endothelial cells (ECs) (Gimbrone and Garca-Cardea 2016

The criteria of bronchial and bronchiolar epithelial degeneration and necrosis, luminal inflammation, interstitial and alveolar edema, hemorrhage, inflammation, perivascular inflammation and vascular congestion were graded as follows: (0) normal histology, (1) mild 50% tissue damage