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However, because the study was not blinded, placebo-controlled, or randomized, it's not possible to determine if Pycnogenol actually improved symptoms

doi: 10.1126/science.aaq0216

Hoffberger-Pippan, Elisabeth

Unlike most GHSs, which have peptide structures and require injections for successful administration, MK-677 boasts an oral bioavailability of over 60% and a half-life exceeding 4-5 hours [2]