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OByrne KJ, Dalgleish AG (2001): Chronic immune activation and inflammation as the cause of malignancy

To allow for synchronised development with constant density, embryos were collected on agar plates (2.3% agar, 1% sucrose, and 0.35% acetic acid) with live yeast paste and directly added to the standard diet in a bottle with a fixed volume

Although RB loss confers a certain level of resistance to CDK4 inhibitors, knockdown of RB alone couldnt fully overcome cell cycle arrest induced by CDK4 inhibitors, as shown before 11