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by David Becker, M.D., Philly Inquirer (9.12.2017) A 2016 paper in Physiology & Behavior reported, there is a striking congruence between results from animal research and a number of large-scale, long-term observational studies in humans, in finding significantly increased weight gain, adiposity, incidence of obesity, cardiometabolic risk, and even total mortality among individuals with chronic, daily exposure to low-calorie sweeteners and these results are troubling. Women who consumed more than two diet drinks per day had a higher risk of [cardiovascular disease] events [cardiovascular disease] mortality and overall mortality, according to a 2014 study from the Womens Health Initiative published in the Journal of General Internal Medicine

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Of note, GSTP1/P2 were found in the nucleus of some regenerating hepatocytes