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For example, engineered bacteria can be designed to locally deliver IL-10 or TGF- in the intestinal inflammatory environment to regulate hepatic immunity

Pattipeiluhu and colleagues have introduced a novel mRNA delivery system based on liposome nanoparticles, demonstrating its capability to selectively target the hepatic reticuloendothelial system through in vivo biological distribution and clearance mechanisms by modulating the surface charge from neutral to anionic [150]