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Quarterly dosing is 675 mg administered as three 225 mg SC injections every 3 months

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Community protocols use the 8-week on/off structure to reduce the risk of receptor desensitization this hasn't been directly tested in published AOD-9604 trials

Experiments conducted on isolated bovine chondrocytes also revealed an apparent upregulation in the production of proteoglycans and collagen in these laboratory settings, fundamental components of the extracellular matrix considered essential for cartilage integrity