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High-salt diet is an important factor for hypertension, which can deplete Lactobacillus in mice (108), while candesartan can counteract the decrease of Lactobacillus caused by hypertension, and candesartan treatment also increases the intestinal expression of genes encoding tight junction proteins (such as zonula occludens, occludin, and claudin-1), improving increased intestinal permeability caused by hypertension and preventing gut microbiota translocation (105)

concentrations drop by more than half between age 20 and 60

Research demonstrates that BNIP3/NIX-mediated mitophagy orchestrates mitochondrial dynamics homeostasis through dual regulatory mechanisms: by suppressing the activity of fusion protein Opa1 while enhancing fission protein Drp1 functionality to induce mitochondrial network fragmentation, thereby facilitating segregation of damaged organelles

Risk factors of herpes simplex type 1 (HSV-1) infection and lifestyle factors associated with HSV-1 manifestations