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and Mwacalimba et al

Ng Published: Endocrinology, Volume 142, Issue 12, December 2001, Pages 51825189 DOI: 10.1210/endo.142.12.8522 URL: Mouse and human cell lines were used to assess 3-adrenergic receptor (3-AR) mRNA expression, protein levels, and function following treatment with AOD9604 and human growth hormone (hGH)

A few of the most significant contributors to NAD+ depletion include: CD38: An enzyme that breaks down NAD+ and becomes more active with age, especially in response to inflammation

However, it may also result from a range of underlying health conditions, like chronic pancreatitis, SIBO, and malabsorption disorder