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TABLE 2 Key epidemiological and clinical studies on chronic constipation-depression comorbidity (section 3)

Dutkowski, P., et al

Recently, Lozano and collaborators demonstrated that in melanoma patients treated with anti-PD-1 or anti-PD-1 and anti-CTLA-4 combination, two pretreatment factors in peripheral blood - activated CD4 memory T cell abundance and TCR diversity - were associated with severe irAEs development (79)